Author

D. Needleman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Assay:imaging· 3 Organism:C. elegans· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:electronic health records· 1

Frequent Co-Authors

H.-Y. Wu· 3 shared R. Kiewisz· 3 shared C.-H. Yu· 2 shared G. Fabig· 2 shared M. Anjur-Dietrich· 2 shared R. Farhadifar· 2 shared S. Redemann· 2 shared T. Muller-Reichert· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCell Biology

H.-Y. Wu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

KLP-19 controls microtubule length in the spindle midzone of C. elegans, affecting spindle dynamics and force transmission during mitosis.

V. Zimyanin, M. M. Magaj, N. I. Manzi, C.-H. Yu, T. V. Gibney, Y.-Z. Chen, B. Mustafa, X. Horton, K. Siller, A. M. Pani, D. Needleman, D. J. Dickinson, S. Redemann

The paper identifies KLP-19's role in regulating microtubule length in the C. elegans spindle midzone, impacting spindle dynamics and force transmission during mitosis.

Journal of Cell Science · Aug 15, 2026Peer-reviewedCell Biology

Clustering of cortical dynein regulates the mechanics of spindle orientation in human mitotic cells

M. Anjur-Dietrich, V. G. Hererra, R. Farhadifar, H.-Y. Wu, H. Merta, S. Bahmanyar, M. Shelley, D. Needleman

This study measures forces on human mitotic spindles and shows that cortical dynein clustering determines spindle orientation mechanics.

bioRxiv · Sep 11, 2023 · PreprintCell Biology

Three-dimensional structure of the kinetochore-fibers in human mitotic spindles

R. Kiewisz, G. Fabig, W. Conway, D. Baum, D. Needleman, T. Muller-Reichert

This paper uses electron tomography to reveal the 3D structure of kinetochore-fibers in human mitotic spindles, showing nine KMTs per fiber and structural variations along their length.

bioRxiv · Nov 13, 2021Cell Biology

Self-organization of kinetochore-fibers in human mitotic spindles

W. Conway, R. Kiewisz, G. Fabig, C. P. Kelleher, H.-Y. Wu, M. Anjur-Dietrich, T. Mueller-Reichert, D. Needleman

This study investigates how kinetochore microtubules (KMTs) organize in human mitotic spindles using electron tomography, experiments, and modeling, finding that KMTs grow along defined trajectories and predominantly nucleate de novo at kinetochores.

bioRxiv · Nov 11, 2021Biophysics

Central spindle microtubules are strongly coupled to chromosomes during both anaphase A and anaphase B

C.-H. Yu, S. Redemann, H.-Y. Wu, R. Kiewisz, T. Y. Yoo, R. Farhadifar, T. Muller-Reichert, D. Needleman

The paper measures central spindle microtubule movement during chromosome segregation in human and C. elegans spindles, finding they slide apart at the same speed as chromosomes and are strongly coupled to them.

bioRxiv · Jan 31, 2019Cell Biology