D. Baum

MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles

This study uses electron tomography to show that MT minus ends in mitotic spindles are heterogeneous, with MCRS1 modulating their open/closed states.

Three-dimensional structure of the kinetochore-fibers in human mitotic spindles

This paper uses electron tomography to reveal the 3D structure of kinetochore-fibers in human mitotic spindles, showing nine KMTs per fiber and structural variations along their length.

Automated segmentation of insect anatomy from micro-CT images using deep learning

This paper develops a deep learning pipeline for automated segmentation of insect anatomy from micro-CT images, achieving high accuracy and efficiency compared to manual methods.

Semi-automatic stitching of filamentous structures in image stacks from serial-section electron tomography

The paper presents a semi-automatic workflow for aligning and stitching filamentous structures in serial-section electron tomography data to improve 3D reconstruction of microtubules in spindles.

Establishing cell-intrinsic limitations in cell cycle progression controls graft growth and promotes differentiation of pancreatic endocrine cells

The paper investigates how limitations in S-phase progression affect pancreatic endocrine differentiation and graft growth, finding that impaired DNA replication enhances differentiation and prevents cystic growth.