Specific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma
D. Gannon, E. Lagan, A. J. Silva, P. Bibawi, A. Doherty, D. Nimmo, R. McCole, C. Monger, G. Genesi, A. Vanderlinden Dibekeme, J. Innes, L. Yang, B. Chen, G. van Mierlo, P. W. Jansen, , G. Brien
The paper identifies specific cPRC1 complexes, CBX4/PCGF4, that mediate oncogenic gene repression in DMG cells downstream of H3K27M mutation.
bioRxiv · Dec 2, 2023Cancer Biology