Head-to-head comparison of CCN4, DNMT3A, PTPN11, and SPARC as suppressors of anti-tumor immunity
A. C. Pirkey, W. Deng, D. Norman, A. Razazan, D. J. Klinke
This study identifies CCN4 as a secreted factor mediating immunosuppression in melanoma and shows its knockout improves immune-mediated tumor control in immunocompetent mice.
bioRxiv · Apr 1, 2022Cancer Biology