W. Deng

RAPMS 2.0 Improves Specificity and Throughput for Proteomic Identification of RNA Binding Proteins

RAP-MS 2.0 improves specificity and throughput for identifying RNA-binding proteins by reducing background and enabling reuse of lysate for multiple RNA captures.

Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma

The paper identifies a mature dendritic cell subtype associated with improved immune response and prognosis in melanoma patients treated with anti-PD-1 checkpoint inhibitors.

MIPDB: A maize image-phenotype database with multi-angle and multi-time characteristics

The paper introduces MIPDB, a maize image-phenotype database with multi-angle and multi-time images, providing a high-quality dataset for deep learning-based phenomics research.

Characterization of Genome-wide Phylogenetic Conflict Uncovers Evolutionary Modes of Carnivorous Fungi

The paper uses phylogenomic analyses of 23 genomes to study evolutionary modes of carnivorous fungi, finding extensive phylogenetic discordance due to incomplete lineage sorting and non-vertical evolution.

The Genomes of Nematode-Trapping Fungi Provide Insights into the Origin and Diversification of Fungal Carnivorism

This study compares the genomes of nematode-trapping fungi and non-NTF to identify genomic changes linked to carnivorism and adaptation to post-Permian-Triassic extinction environments.

Respiration and growth of Paracoccus denitrificans R-1 with nitrous oxide as an electron acceptor

This study investigates the ability of Paracoccus denitrificans R-1 to use nitrous oxide as an electron acceptor for energy generation and growth, showing it can reduce N2O to N2 under anaerobic conditions.

Quorum Sensing Modulates Bacterial Virulence and Colonization Dynamics During an Enteric Infection

This study shows that quorum sensing in Citrobacter rodentium regulates virulence and colonization during infection, with QS inhibition sometimes increasing virulence.

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

Discovery and remodeling of Vibrio natriegens as a microbial platform for efficient formic acid biorefinery

This paper discovers Vibrio natriegens as a microbial platform for efficient formic acid utilization and remodeled it to enhance formate consumption and indigoidine production.

Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation

The paper shows that fever increases inflammatory activity in CD4+ T cells but causes mitochondrial dysfunction and DNA damage specifically in Th1 cells, leading to p53-dependent apoptosis to prevent mutations.

Extinction drives a discontinuous temporal pattern of species-area relationships in a microbial microcosm system

This study shows that extinction drives a temporally discontinuous species-area relationship in microbial microcosms, with small-scale extinctions promoting stability and mass extinctions resetting the system.

Gaq-PKD/PKCμ regulates the IkB transcription to limit the NF-kB mediated inflammatory response essential for early pregnancy

This study shows that Gaq-PKD/PKCμ regulates IκB transcription to limit NF-κB-mediated inflammation, essential for successful early pregnancy.

Spatiotemporal landscape of SARS-CoV-2 pulmonary infection reveals Slamf9+Spp1+ macrophages promoting viral clearance and inflammation resolution

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

Head-to-head comparison of CCN4, DNMT3A, PTPN11, and SPARC as suppressors of anti-tumor immunity

This study identifies CCN4 as a secreted factor mediating immunosuppression in melanoma and shows its knockout improves immune-mediated tumor control in immunocompetent mice.

SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization

This study identifies SOX4 as a critical regulator of human endometrial decidualization by modulating PGR stability and FOXO1 expression, linking its dysregulation to infertility and pregnancy complications.

AxonDeep: Automated Optic Nerve Axon Segmentation in Mice with Deep Learning.

AxonDeep uses deep learning to automate axon segmentation and quantification in mouse optic nerves, achieving performance comparable to experts while reducing variability and time.

Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma

This study shows that CCN4 promotes immunosuppression in melanoma by reducing CD8+ T cells and increasing MDSCs, and that its removal enhances immune checkpoint therapy effectiveness.

Small molecules inhibit SARS-COV-2 induced aberrant inflammation and viral replication in mice by targeting S100A8/A9-TLR4 axis

A new method for distinguishing human and mouse cells in situ

This paper introduces a method using DAPI staining to distinguish human and mouse cells in situ, showing distinct nuclear structures in mouse cells.

Latent motives guide structure learning during adaptive social choice

The paper shows humans predict others' behavior by inferring their hidden motives, enabling strategic social interactions across different contexts.

Rapid development of an inactivated vaccine for SARS-CoV-2

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

Lack of Reinfection in Rhesus Macaques Infected with SARS-CoV-2

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in Rhesus macaques

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

Protection of Rhesus Macaque from SARS-Coronavirus challenge by recombinant adenovirus vaccine

This study shows a recombinant adenovirus vaccine protects rhesus macaques from SARS-CoV challenge by inducing immune responses and reducing lung damage.

The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

Interleukin-12 elicits a non-canonical response in B16 melanoma cells to enhance survival

This study shows IL-12 enhances B16F0 melanoma cell survival through non-canonical PI3K-AKT signaling, distinct from its canonical role in immune cells.

Spatial and temporal control of CRISPR/Cas9-mediated gene editing delivered via a light-triggered liposome system

This study develops a light-triggered liposome system for spatial and temporal control of CRISPR/Cas9 gene editing, achieving high knockout efficiency in both in vitro and in vivo models.

Cell Communication Network factor 4 (CCN4/WISP1) shifts melanoma cells from a fragile proliferative state to a resilient metastatic state

This study shows CCN4 promotes melanoma metastasis by shifting cells from a proliferative to a resilient state, with implications for therapy and biomarker development.

Structural insight into the mechanism of 4-aminoquinolines selectivity for the alpha2A-adrenoceptor

This study investigates the selectivity of 4-aminoquinolines for the alpha2A-adrenoceptor using docking, molecular dynamics, and mutagenesis to identify binding sites and affinity determinants.

RUNX/CBFβ transcription factor complexes promote the phenotypic plasticity of metastatic breast cancer cells

This study shows that RUNX/CBFβ complexes drive phenotypic plasticity in metastatic breast cancer cells by promoting EMT and enabling MET reversal.