Type I interferon drives a cellular state inert to TCR-stimulation and could impede effective T-cell differentiation in cancer
D. Corvino, M. Batstone, B. G. M. Hughes, T. Kempchen, S. S. Ng, N. Salim, F. Schneppenheim, D. Rommel, A. Kumar, S. Pearson, J. Madore, L. T. Koufariotis, L. M. Steinheuer, D. Pathirana, K. Thurley, , T. Bald
The paper identifies a subset of CD8+ TILs in HPV-HNSCC enriched for interferon-stimulated genes that are transcriptionally inert to TCR stimulation and may hinder T-cell differentiation.
bioRxiv · Mar 28, 2024Immunology