Author

S. Pearson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biochemistry· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

J. E. Allen· 3 shared T. E. Sutherland· 3 shared J. Ajendra· 2 shared J. E. Parkinson· 2 shared A. Cowan· 1 shared A. Kumar· 1 shared A. L. Chenery· 1 shared B. G. M. Hughes· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersImmunology

J. E. Allen

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Author profile →

7 papers

Recent·Most cited

Type I interferon drives a cellular state inert to TCR-stimulation and could impede effective T-cell differentiation in cancer

D. Corvino, M. Batstone, B. G. M. Hughes, T. Kempchen, S. S. Ng, N. Salim, F. Schneppenheim, D. Rommel, A. Kumar, S. Pearson, J. Madore, L. T. Koufariotis, L. M. Steinheuer, D. Pathirana, K. Thurley, , T. Bald

The paper identifies a subset of CD8+ TILs in HPV-HNSCC enriched for interferon-stimulated genes that are transcriptionally inert to TCR stimulation and may hinder T-cell differentiation.

bioRxiv · Mar 28, 2024Immunology

IL-17A promotes epithelial cell IL-33 production during nematode lung migration

J. Ajendra, S. Pearson, J. Parkinson, B. H. K. Chan, H. J. McSorley, T. E. Sutherland, J. E. Allen

This study shows IL-17A promotes IL-33 production in lung epithelial cells during nematode infection, independent of IFN-gamma suppression.

bioRxiv · Nov 3, 2022 · PreprintImmunology

The UIP honeycomb airway cells are the site of mucin biogenesis with deranged cilia

J. A. Herrera, L. A. Dingle, M. A. Montero, V. Rajamiyer, J. Blaikley, F. Granato, S. Pearson, C. Lawless, D. J. Thornton

The paper uses spatial proteomics to compare fibrotic and non-fibrotic airway cells in UIP, finding deregulated pathways and identifying key proteins associated with mucin biogenesis and ciliogenesis.

bioRxiv · Sep 3, 2022Pathology

The magnitude of airway remodelling is not altered by distinct allergic inflammatory responses in BALB/c vs C57BL/6 mice but matrix composition differs

J. E. Parkinson, S. Pearson, D. Ruckerl, J. E. Allen, T. E. Sutherland

bioRxiv · Oct 20, 2020Immunology

IL-17A both initiates (via IFNγ suppression) and limits the pulmonary type 2 immune response to nematode infection

J. Ajendra, A. L. Chenery, J. E. Parkinson, B. H. Chan, S. Pearson, S. A. Colombo, L. Boon, R. K. Grencis, T. E. Sutherland, J. E. Allen

This study shows IL-17A suppresses IFNγ to initiate and later limits type-2 immune responses in the lung during nematode infection.

bioRxiv · Apr 18, 2020Immunology

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

V. Panic, S. Pearson, J. Banks, T. S. Tippetts, S. Lee, J. Simcox, G. Geoghegan, C. Bensard, T. van Ry, W. L. Holland, S. Summers, J. Cox, G. Ducker, J. Rutter, C. Villanueva

This study shows that mitochondrial pyruvate carrier is essential for optimal brown fat thermogenesis, as its deletion impairs cold adaptation and alters metabolic pathways.

bioRxiv · Oct 29, 2019Biochemistry

Vector-Mediated Transport Producing Drug-like Peptides

K. A. Gruber, J. A. Cowan, A. Cowan, W. Qi, S. Pearson, M. J. Ross, C. Wachnowsky, F. Gallazzi, S. Jiang, S. R. Van Doren, M. F. Callahan

This paper develops a vector-mediated transport approach to create drug-like peptides with oral activity, blood-brain-barrier transport, and extended in vivo half-life.

bioRxiv · Dec 28, 2018 · PreprintPharmacology & Toxicology