S. S. Ng

The paper identifies Angptl4's role in shaping intrahepatic T-cell activation via eIF2α signaling during fibrosis in diet-induced NAFLD.

A small molecule screen in patient iPSCs with in vivo validation in mice identifies LRRK2 as a new therapeutic target for Alpha-1 Antitrypsin Deficiency.

This study shows that Matriptase promotes tissue damage responses by activating Gq signaling, leading to RSK and DUOX activation, which disrupts epithelial junctions and contributes to inflammation and carcinoma.

This study shows that deamidated fibronectin with isoDGR motifs promotes vascular fibrosis and atherosclerosis by enhancing integrin signaling and leukocyte recruitment.

This study shows that mature hepatocytes can autonomously polarize to form secretory hemi-apical lumens on bio-functionalized substrates, enabling controlled study of lumenogenesis.