Thymidylate synthase maintains the de-differentiated state of aggressive breast cancers
A. Siddiqui, P. N. Gollavilli, A. Schwab, M. E. Vazakidou, P. Ersan, M. Ramakrishnan, D. Pluim, S. A. Coggins, O. Saatci, L. Annaratone, J. H. Schellens, B. Kim, I. A. Asangani, S. A. K. Rasheed, C. Marchio, , P. Ceppi
This study shows that thymidylate synthase promotes de-differentiation in aggressive breast cancers by supporting pyrimidine catabolism and EMT, correlating with poor prognosis.
Cell Death & Differentiation · Nov 1, 2019Peer-reviewedCancer Biology