A. Siddiqui

A Clinically Useful and Biologically Informative Genomic Classifier for Papillary Thyroid Cancer

The paper develops a genomic classifier for papillary thyroid cancer using machine learning, identifying molecular subtypes with distinct prognostic and therapeutic implications.

Protein Coronas on Functionalized Nanoparticles Enable Quantitative and Precise Large-Scale Deep Plasma Proteomics

This paper demonstrates that nanoparticle-based proteomics workflows enable accurate and scalable deep plasma proteomics with high precision and statistical power for biomarker discovery.

Enhanced competitive protein exchange at the nano-bio interface enables ultra-deep coverage of the human plasma proteome

The paper develops a method using engineered nanoparticles to enhance plasma proteome coverage by optimizing protein-NP interactions and competition, resulting in deeper and more consistent proteomic profiling.

Functionally distinct BMP1 isoforms show an opposite pattern of abundance in plasma from non-small cell lung cancer subjects and controls

The paper identifies BMP1 isoforms with opposite abundance patterns in NSCLC and control plasma proteomes, suggesting differential regulation linked to disease progression.

Spatial heterogeneity in resources alters selective dynamics in Drosophila melanogaster

This study examines how spatial resource heterogeneity affects natural and sexual selection in Drosophila melanogaster by testing allele purging dynamics across different spatial environments.

A Second Generation Leishmanization Vaccine with a Markerless Attenuated Leishmania major Strain using CRISPR gene editing

This paper describes a CRISPR-edited Leishmania major strain for a second-generation leishmanization vaccine that is marker-free and safe, showing protection in mice comparable to traditional leishmanization.

Thymidylate synthase maintains the de-differentiated state of aggressive breast cancers

This study shows that thymidylate synthase promotes de-differentiation in aggressive breast cancers by supporting pyrimidine catabolism and EMT, correlating with poor prognosis.