Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control
A. R. Ormsby, D. Cox, J. Daly, D. Priest, E. Hinde, D. M. Hatters
This study investigates how mutant Huntingtin exon 1 chains form inclusions in cells, finding that nascent chains do not stall on ribosomes but that ribosome quality control proteins are recruited into the aggregates.
bioRxiv · May 13, 2020Cell Biology