Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex
B. G. Williams, L. D. W. King, D. Pulido, D. Quinker, A. M. Lias, S. E. Silk, R. J. Ragotte, H. Davies, J. R. Barrett, K. McHugh, C. A. Rigby, D. G. W. Alanine, L. Barfod, M. W. Shea, L. A. Cowley, , S. J. Draper
This paper develops a combination malaria vaccine targeting the RCR-complex by fusing epitopes from RIPR to CyRPA, improving in vitro growth inhibition compared to RH5.1 alone.
Nature Communications · Jun 7, 2024Peer-reviewedImmunology