S. J. Draper

The paper characterizes human antibodies against PfRH5, identifies key features of potent inhibitors, and demonstrates their prophylactic potential against malaria.

This study evaluates the precision of the Plasmodium knowlesi growth inhibition assay for Plasmodium vivax Duffy-binding protein-based malaria vaccine development, finding significant assay-to-assay variation in %GIA and GIA50.

This paper develops a stabilized RH5 VLP vaccine that induces improved anti-malarial antibodies compared to a soluble protein vaccine in preclinical studies.

The paper identifies potent neutralizing antibodies against the malaria antigen RH5 from natural infection, showing they target similar epitopes as vaccine-induced antibodies.

This paper evaluates the invasion inhibition of Plasmodium knowlesi transgenic parasites expressing PvDBP by naturally acquired and vaccine-induced human monoclonal antibodies, finding additive and antagonistic effects in combinations.

This paper shows that antibodies against PfRH5 and PfCyRPA block parasite invasion and inactivate extracellular merozoites by triggering a developmental pathway normally seen after invasion.

This study shows that hybrid immunity from infection plus vaccination generates durable lung mucosal immunity, while peripheral vaccination alone does not.

This paper describes a method to enhance adenovirus vaccine efficacy by decorating capsid surfaces with antigens, resulting in improved humoral immunity and retained T cell responses.

This study shows that low-dose adenovirus vaccines administered via microneedle patches to the skin induce better functional antibody responses than systemic injection.

This study shows that SARS-CoV-2 spike glycoprotein does not directly interact with human basigin (CD147), challenging its role as a co-receptor for viral entry.

The paper determines the structure of the RH5-binding region of P113 and identifies the binding site, providing insights for malaria vaccine development.

This study develops CRISPR-Cas9 genome editing in Plasmodium knowlesi to generate a transgenic line expressing P. vivax Duffy binding protein, showing its role in host cell tropism and vaccine potential.

This paper develops a simian-adenovirus-vectored rabies vaccine that can be thermostabilized and administered as a single dose, showing potent immunogenicity and potential for low-cost pre-exposure prophylaxis.