A pals-25 gain-of-function allele triggers systemic resistance against natural pathogens of C. elegans
S. S. Gang, M. Grover, K. C. Reddy, D. Raman, Y.-T. Chang, D. C. Ekiert, M. Barkoulas, E. R. Troemel
This paper identifies a PALS-25 gain-of-function mutant in C. elegans that activates immune responses against both epidermal and intestinal pathogens through cross-tissue signaling.
bioRxiv · Jun 28, 2022Immunology