N. Joshi

LCN2 promotes focal adhesion formation and invasion by stimulating Src activation.

This study shows LCN2 promotes invasion by enhancing focal adhesion formation through Src activation, independent of its iron-binding ability.

A Mechanically Resilient Soft Hydrogel Improves Drug Delivery for Treating Post-Traumatic Osteoarthritis in Physically Active Joints

This paper develops a mechanically resilient hydrogel for drug delivery in physically active joints, showing sustained release and reduced cartilage degeneration in a mouse model of post-traumatic osteoarthritis.

Mechanically Tunable, Compostable, Healable and Scalable Engineered Living Materials

This paper introduces MECHS, a compostable, healable, and scalable engineered living material made from bacterial biomass with tunable mechanical properties.

Ultra-Long-Term Delivery of Hydrophilic Drugs Using Injectable In Situ Cross-Linked Depots

This paper develops an injectable platform for ultra-long-term hydrophilic drug delivery, achieving sustained release over six months in vivo.

A Drug-Free Pathogen Capture and Neutralizing Nasal Spray to Prevent Emerging Respiratory Infections

This paper introduces a drug-free nasal spray that captures and neutralizes respiratory pathogens, showing high efficacy in mice against influenza.

Effect of Organic and Chemical Fertilizers on the Nutritional Composition of Amaranthus spinosus

The study compares the effects of organic, chemical, and combined fertilizers on the nutritional composition of Amaranthus spinosus, finding that organic fertilizers or their combination with chemical fertilizers improve phytochemical and mineral content.

Generation of transducible version of a recombinant human HAND2 transcription factor from Escherichia coli

This paper describes the generation and characterization of a recombinant human HAND2 fusion protein expressed in E. coli, showing its ability to transduce human cells and retain structural integrity.

Targeting the artemisinin resistant malaria by repositioning of the anti-Hepatitis C Virus drug Alisporivir

This study repositions Alisporivir, an anti-Hepatitis C drug, as a potential treatment for artemisinin-resistant malaria by targeting PfCyP-19B, which is overexpressed in resistant parasites.

Antimalarial and Plasmodium falciparum serpentine receptor 12 targeting effect of a purinergic receptor antagonist FDA approved drug

This study evaluates the antimalarial effect of Prasugrel, an FDA-approved purinergic receptor antagonist, on Plasmodium falciparum by targeting PfSR12, a putative purinergic receptor.

Metalloprotease Gp63 targeting novel glycoside exhibits potential antileishmanial activity

This study identifies a glycoside derivative, Gly 2, with potent antileishmanial activity against Leishmania donovani, targeting the metalloprotease Gp63 and showing efficacy against both visceral leishmaniasis and post-kala-azar dermal leishmaniasis.

BBB pathophysiology independent delivery of siRNA in traumatic brain injury

This paper develops a nanoparticle platform for BBB-independent siRNA delivery in TBI, achieving higher brain accumulation and gene silencing through surface chemistry and coating density modulation.

Resetting proteostasis with ISRIB prevents pulmonary fibrosis

ISRIB reduces pulmonary fibrosis severity in young and old mice by modulating stress response signaling in alveolar epithelial cells.

Single-cell RNA-seq reveals spatially restricted multicellular fibrotic niches during lung fibrosis

The paper identifies monocyte-derived alveolar macrophages as causally linked to fibrosis in lung tissue through autocrine signaling and fibroblast activation.

Impaired phagocytic function in CX3CR1+ tissue-resident skeletal muscle macrophages prevents muscle recovery after influenza A virus-induced pneumonia in aged mice

Proteostasis and Energetics as Proteome Hallmarks of Aging and Influenza Challenge in Pulmonary Disease

This study examines proteome changes in alveolar macrophages and type 2 cells from young and old mice before and after influenza infection, revealing age-related proteostasis and mitochondrial dysfunction that worsen with infection.

The Aging Microenvironment Shapes Alveolar Macrophage Identity in Aging

This study shows that the aging lung microenvironment shapes alveolar macrophage identity, influencing their phenotype during aging and after injury.

Temporally feathered intensity modulated radiation therapy: a planning technique to reduce normal tissue toxicity

This paper introduces a novel radiation therapy planning technique called temporally feathered radiotherapy (TFRT) that reduces normal tissue toxicity by optimizing the timing of radiation doses.