RELA is Sufficient to Mediate Interleukin-1 (IL-1) Repression of Androgen Receptor Expression and Activity in LNCaP Disease Progression Model
S. Thomas-Jardin, H. Dahl, M. Kanchwala, F. Ha, J. Jacob, R. Soundharrajan, M. Bautista, A. Nawas, D. Robichaux, R. Mistry, V. Anunobi, C. Xing, N. Delk
This study shows that RELA mediates IL-1 repression of AR mRNA and activity in PCa cells, with stronger effects in castration-resistant sublines.
bioRxiv · Sep 19, 2019Cancer Biology