C. Xing

AB-free kava enhances resilience against the adverse health effects of tobacco smoke in mice

This study evaluates AB-free kava's effects on tobacco smoke-exposed mice, showing it mitigates health deficits with safety, suggesting potential for reducing tobacco-related harm.

Opto-chemogenetic inhibition of L-type CaV1 channels in neurons through a membrane-assisted molecular linkage

This paper develops a method to inhibit L-type CaV1 channels in neurons using opto-chemogenetic tools, showing acute and potent inhibition through membrane-assisted molecular linkage.

Fucosylated glycoproteins and fucosylated glycolipids play opposing roles in cholera intoxication

This study identifies fucosylated glycoproteins and glycolipids as opposing factors in cholera toxin binding and intoxication in intestinal cells.

Rapid and visual detection of Schistosoma japonicum circulating nucleic acids by CRISPR-Cas12a

This paper develops a CRISPR-Cas12a-based method for detecting Schistosoma japonicum circulating nucleic acids with high sensitivity and specificity, validated using rabbit serum samples.

Evolution of the gene regulatory network of body axis by enhancer hijacking in amphioxus

The paper investigates the evolution of a gene regulatory network in amphioxus, showing that enhancer hijacking allowed a new GRN to emerge through the functional shift of Gdf1/3-like to replace Gdf1/3 in axial development.

Molecular features driving condensate formation and gene expression by the BRD4-NUT fusion oncoprotein are overlapping but distinct

This study identifies molecular features of BRD4-NUT and its interaction with p300 that drive condensate formation and gene expression, showing overlapping yet distinct roles of p300 domains.

Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14

The paper shows that a cancer mutation in METTL14 changes RNA methylation specificity, promoting oncogenesis by altering gene expression without increasing global m6A levels.

Interferon inhibits a model RNA virus via a limited set of inducible effector genes

This study identifies a limited set of interferon-stimulated genes that mediate antiviral effects against Venezuelan equine encephalitis virus.

Urinary Glycosaminoglycans are Associated with Recurrent UTI and Urobiome Ecology in Postmenopausal Women

This study examines urinary glycosaminoglycan (GAG) composition in postmenopausal women and links it to recurrent UTI and urobiome ecology.

Genome-scale CRISPR screening reveals host factors required for ribosome formation and viral replication

The paper identifies host factors required for ribosome formation and viral replication using CRISPR screening, showing that SPATA5 and SBDS are broadly needed for multiple virus types.

A fast-killing tyrosine amide ((S)-SW228703) with blood and liver-stage antimalarial activity associated with the Cyclic Amine Resistance Locus (PfCARL)

This paper identifies (S)-SW228703, a tyrosine amide with fast-killing antimalarial activity against blood and liver stages of Plasmodium falciparum, and links resistance to mutations in PfCARL and PfACT.

Synthetic fibrous hydrogels as a platform to decipher cell-matrix mechanical interactions

This study uses synthetic fibrous hydrogels to investigate cell-matrix mechanical interactions and their impact on cellular behavior.

Tau seeds translocate across the cell membrane to initiate aggregation

This study identifies a novel mechanism by which tau seeds enter cells and initiate aggregation through direct translocation across the plasma membrane, independent of endocytosis.

Genome editing in the unicellular holozoan Capsaspora owczarzaki suggests a premetazoan role for the Hippo pathway in multicellular morphogenesis

This study uses genome editing in Capsaspora owczarzaki to show that the Hippo pathway ortholog coYki regulates cytoskeletal dynamics and multicellular shape, suggesting an ancestral role in multicellular morphogenesis.

Recurrent urinary tract infection and estrogen shape the taxonomic ecology and functional potential of the postmenopausal urobiome

This study investigates how recurrent UTI and estrogen influence the urobiome's taxonomic and functional features in postmenopausal women using metagenomic and metabolomic analyses.

SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells

This study identifies SLC25A39 as a mitochondrial glutathione importer and shows its role in cell proliferation and red blood cell development, with GSH availability regulating its abundance.

NNAL, a major metabolite of tobacco-specific carcinogen NNK, promotes lung cancer progression through deactivating LKB1 in an isomer-dependent manner

This study shows that (R)-NNAL promotes lung cancer progression by deactivating LKB1 through β-AR signaling, while (S)-NNAL has weaker effects.

STING mediates immune responses in the closest living relatives of animals

This study shows that STING mediates antibacterial immunity in the choanoflagellate M. brevicollis, a close relative of animals, and identifies its role in pathogen sensing and autophagy.

Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis

This study identifies adducin as a regulator of sarcomere disassembly during cardiomyocyte mitosis, showing phosphorylation of a short isoform induces disassembly in neonatal cardiomyocytes.

High-throughput, low-cost and rapid DNA sequencing using surface-coating techniques

This paper introduces a surface-coating technique to improve DNA sequencing speed, cost, and throughput for genomic applications.

Manipulation of IRE1-dependent MAPK signaling by a Vibrio agonist-antagonist effector pair

This paper shows how Vibrio parahaemolyticus uses two effectors, VopQ and VopS, to manipulate host signaling by first inducing pro-survival responses and then triggering cell death.

Chronic IL-1 exposure drives LNCaP cells to evolve androgen and AR independence

This study shows chronic IL-1 exposure leads to androgen and AR independence in LNCaP prostate cancer cells, promoting castration-resistant prostate cancer development.

Changes in the expression of interleukin-10 in myocardial infarction and its relationship with macrophage activation and cell apoptosis

This study examines changes in IL-10 expression in myocardial infarction and its association with macrophage activation and cardiomyocyte apoptosis over time.

IL-1-conferred gene expression pattern in ERα+ BCa and AR+ PCa cells is intrinsic to ERα- BCa and AR- PCa cells and promotes cell survival

The paper identifies a 350-gene set conserved between HR+ and HR- BCa/PCa cells that promotes HR-independent survival and treatment resistance.

RELA is Sufficient to Mediate Interleukin-1 (IL-1) Repression of Androgen Receptor Expression and Activity in LNCaP Disease Progression Model

This study shows that RELA mediates IL-1 repression of AR mRNA and activity in PCa cells, with stronger effects in castration-resistant sublines.

Modification of T cells function after restoration of spontaneous circulation in a rat model of cardiac arrest

This study examines T cell function changes in a rat cardiac arrest model after ROSC, finding reduced T cells, increased co-inhibitory molecules, and a shift from Th1 to Th2 responses.

The IFN response in bat cells consists of canonical and non-canonical ISGs with unique temporal expression kinetics

This study identifies canonical and non-canonical ISGs in bat cells with distinct temporal expression kinetics, revealing unique aspects of the IFN response that may contribute to viral resistance.