CD39+ conventional CD4+ T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade
S. N. Bossio, C. Abrate, J. Tosello Boari, C. Rodriguez, F. Canale, M. C. Ramello, W. Richer, D. Rocha, C. Sedlik, A. Salomon, E. Borcoman, A. del Castillo, A. Gruppi, E. Fernandez, E. V. Acosta Rodriguez, C. L. Montes
The paper identifies CD39+ CD4+ T cells in tumors with exhaustion and cytotoxic traits, showing their expansion with CTLA-4 blockade and association with better survival in breast cancer.
bioRxiv · Jan 30, 2023Immunology