Cryo-EM visualization of an active high open probability CFTR ion channel
J. F. Fay, L. A. Aleksandrov, T. J. Jensen, L. L. Cui, J. N. Kousouros, L. He, A. A. Aleksandrov, D. S. Gingerich, J. Riordan, J. Z. Chen
The paper determines the structure of active and inactive states of a thermostabilized CFTR channel using cryo-EM, revealing structural changes related to channel function.
bioRxiv · Mar 2, 2018Biophysics