High salt intake activates the hypothalamic-pituitary-adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice
H. M. Costello, G. Krilis, C. Grenier, D. Severs, J. R. Ivy, M. Nixon, M. C. Holmes, D. E. W. Livingstone, E. J. Hoorn, N. Dhaun, M. A. Bailey
This study shows that high salt intake in mice activates the HPA axis, increases glucocorticoid exposure in multiple tissues, and enhances stress responses.
bioRxiv · Mar 4, 2022Physiology