Screening of candidate substrates and coupling ions of transporters by thermostability shift assays
H. Majd, M. King, S. M. Palmer, A. Smith, L. Elbourne, I. Paulsen, D. Sharples, P. Henderson, E. R. S. Kunji
This paper introduces a high-throughput screening method to identify transporter substrates using thermostability shift assays, successfully identifying substrates from unlabeled compound libraries.
bioRxiv · Jul 13, 2018Biophysics