M. King

Ancient Borrelia genomes document the evolutionary history of louse-borne relapsing fever

The paper analyzes ancient Borrelia genomes to document the evolutionary transition from tick-borne to louse-borne transmission and shows rapid reductive evolution.

Condenzymes: Biomolecular condensates with inherent catalytic activities

The paper discovers that intrinsically disordered proteins form condensates with catalytic activity through sequence-dependent electrochemical microenvironments, enabling hydrolysis reactions and gene circuit activation in cells.

Piezo inhibition prevents and rescues scarring by targeting the adipocyte to fibroblast transition

This study shows that inhibiting Piezo1 or Piezo2 prevents adipocyte-to-fibroblast transition, reducing scarring in wounds and suggesting a therapeutic target for fibrosis.

Deletion of arrestin-3 does not improve compulsive drug- seeking behavior in a longitudinal paradigm of oral morphine self-administration

This study shows that deleting arrestin-3 does not reduce compulsive drug-seeking behavior in mice using morphine, suggesting that endogenous signaling patterns involving arrestin-3 may reduce opioid abuse.

Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ

The paper presents the cryo-EM structure of the activated Roq1 NLR bound to XopQ, revealing direct effector recognition and resistosome activation mechanism.

CD47 prevents the elimination of diseased fibroblasts in scleroderma

This study shows that CD47 protects scleroderma fibroblasts from immune elimination and that blocking CD47 with IL6 inhibition can reverse fibrosis in mice.

SS-31 Reverses Mitochondrial Fragmentation in Fibroblasts from Patients with DCMA, a Mitochondrial Cardiomyopathy

This study shows that SS-31 reverses mitochondrial fragmentation and increases ROS in DCMA fibroblasts, suggesting it as a potential therapy for this mitochondrial cardiomyopathy.

Identification of A Disintegrin and Metalloproteinase 9 domain (ADAM9) required in the early stages of encephalomyocarditis virus infection

This study identifies ADAM9 as a host factor required for early stages of EMCV infection using CRISPR-Cas9 screening, showing resistance in ADAM9 knockout cells.

Screening of candidate substrates and coupling ions of transporters by thermostability shift assays

This paper introduces a high-throughput screening method to identify transporter substrates using thermostability shift assays, successfully identifying substrates from unlabeled compound libraries.

Mass Action Kinetic Model of Apoptosis by TRAIL-Functionalized Leukocytes

This paper models the kinetics of TRAIL-induced apoptosis in circulating tumor cells, showing that membrane-bound TRAIL is more effective than soluble TRAIL due to faster apoptosis and reduced clearance.