Inhalation: A means to explore and optimize nintedanib's pharmacokinetic/pharmacodynamic relationship
G. Epstein-Shochet, S. Pham, S. Beck, S. Naiel, O. Mekhael, S. Revill, A. Hayat, M. Vierhout, B. Bardestein-Wald, D. Shitrit, K. Ask, A. B. Montgomery, M. Kolb, M. Surber
This paper investigates the pharmacokinetic/pharmacodynamic relationship of inhaled nintedanib for IPF treatment, showing that short-duration inhaled doses can achieve equivalent or superior efficacy compared to long-duration oral doses.
bioRxiv · Mar 27, 2020Pharmacology & Toxicology