S. Beck

An improved epigenetic counter to track mitotic age in normal and precancerous tissues

This paper develops and validates stemTOC, a DNA methylation-based counter for mitotic age, showing its utility in normal and precancerous tissues for cancer risk prediction.

Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model

The paper examines the role of LYN kinase in BRCA1-defective mammary tumours, finding minimal impact on tumour formation but suggesting B-cell infiltration may influence growth.

Hamsters are a model for post-COVID-19 alveolar regeneration mechanisms: an opportunity to understand post-acute sequelae of SARS-CoV-2

This study shows that Syrian golden hamsters exhibit dysregulated alveolar regeneration after SARS-CoV-2 infection, mirroring post-acute sequelae in humans.

Antibody-mediated depletion of human CLEC-2 in a novel humanised mouse model

This paper develops a humanised CLEC-2 mouse model and a monoclonal antibody to test anti-CLEC-2 therapeutics, showing transient thrombocytopenia without affecting haemostasis.

Progression and Resolution of SARS-1 CoV-2 Infection in Golden Syrian Hamsters

This study tracks SARS-CoV-2 infection progression in golden Syrian hamsters, showing weight loss, lung damage, and resolution over time.

Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma.

This study identifies genes with allele-specific expression in glioblastoma stem cells, finding SLFN11 loss linked to drug resistance and susceptibility to Zika virus.

Epigenetic alterations underlie airway macrophage differentiation and phenotype during lung fibrosis

This study identifies epigenetic changes in airway macrophages from IPF patients, linking them to disease severity and metabolic pathways.

A short course of Tofacitinib sustains the immunoregulatory effect of CTLA4-Ig in presence of inflammatory cytokines and promotes long-term survival of murine cardiac allografts

This study shows that combining Tofacitinib with CTLA4-Ig improves cardiac allograft survival by reducing effector T cells and increasing regulatory T cells in mice.

A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells

This paper shows that K777, a cysteine protease inhibitor, blocks SARS-CoV-2 infection by inhibiting host cathepsin L, which is required for spike protein processing, with nanomolar efficacy in several cell lines.

Machine Learning Models Identify Inhibitors of SARS-CoV-2

The paper uses machine learning to predict SARS-CoV-2 inhibitors from FDA-approved compounds, identifying CPI1062 and CPI1155 as potential antiviral drugs.

Inhalation: A means to explore and optimize nintedanib's pharmacokinetic/pharmacodynamic relationship

This paper investigates the pharmacokinetic/pharmacodynamic relationship of inhaled nintedanib for IPF treatment, showing that short-duration inhaled doses can achieve equivalent or superior efficacy compared to long-duration oral doses.

Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells

This study evaluates the antiviral activity of nucleoside ProTides against Zika virus in human neural stem cells, identifying effective compounds and elucidating their mechanism of action.

Mechanism of action of methotrexate against Zika virus

This study investigates how methotrexate inhibits Zika virus replication by targeting the dihydrofolate reductase pathway and shows that adenosine depletion also contributes to its antiviral effect.

Development and validation of a phenotypic high-content imaging assay for assessing the antiviral activity of small-molecule inhibitors targeting the Zika virus

The paper develops and validates a high-content imaging assay to assess antiviral activity of small-molecule inhibitors against Zika virus by detecting cytopathic effects.