Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
M. Vierhout, A. Ayoub, P. Ali, V. Kumaran, S. Naiel, T. Isshiki, J. F. Koenig, M. R. Kolb, K. Ask
This paper develops an ex vivo model using murine precision-cut lung slices to study profibrotic macrophage polarization and validates its utility for fibrosis research.
bioRxiv · Jul 5, 2024Immunology
Y. Kim, V. Hou, R. D. Huff, J. A. Aguiar, S. Revill, N. Tiessen, C. Cao, M. S. Miller, M. D. Inman, K. Ask, A. C. Doxey, J. A. Hirota
This study shows that inhibiting PDE4 or ABCC4 enhances the anti-inflammatory effects of LABA/GCS in human airway epithelial cells exposed to viral stimuli.
bioRxiv · Nov 9, 2020Immunology
T. Yanagihara, S. G. Chong, M. Gholiof, K. E. Lipson, Q. Zhou, C. Scallan, C. Upagupta, J. Tikkanen, S. Keshavjee, K. Ask, M. R. Kolb
This study shows CTGF contributes to TGF-β1-induced lung fibrosis in a rat model and patients with IPF, and that pamrevlumab can partially reduce fibrosis.
bioRxiv · Jul 4, 2020 · PreprintCell Biology
J. A. Aguiar, B. J.-M. Tremblay, M. J. Mansfield, O. Woody, B. Lobb, A. Banerjee, A. Chandiramohan, N. Tiessen, A. Dvorkin-Gheva, S. Revill, M. S. Miller, C. Carlsten, L. Organ, C. Joseph, A. John, , J. A. Hirota
The paper examines gene expression and protein localization of potential SARS-CoV-2 receptors in human airway epithelial cells and lung tissue, finding low ACE2 expression and confirming other candidate receptors.
bioRxiv · Apr 7, 2020Immunology
G. Epstein-Shochet, S. Pham, S. Beck, S. Naiel, O. Mekhael, S. Revill, A. Hayat, M. Vierhout, B. Bardestein-Wald, D. Shitrit, K. Ask, A. B. Montgomery, M. Kolb, M. Surber
This paper investigates the pharmacokinetic/pharmacodynamic relationship of inhaled nintedanib for IPF treatment, showing that short-duration inhaled doses can achieve equivalent or superior efficacy compared to long-duration oral doses.
bioRxiv · Mar 27, 2020Pharmacology & Toxicology
M. F. Fantauzzi, J. A. Aguiar, B. J.-M. Tremblay, T. Yanagihara, A. Chandiramohan, S. Revill, M. H. Ryu, C. Carlsten, K. Ask, M. Stampfli, A. C. Doxey, J. A. Hirota
The paper analyzes gene expression of the endocannabinoid system in human airway epithelial cells, showing differential expression by disease status and minimal sex impact.
bioRxiv · Mar 1, 2020Cell Biology
Q. T. Cao, J. A. Aguiar, B. J.-M. Tremblay, N. Abbas, N. Tiessen, S. Revill, N. Makhdami, A. Ayoub, G. Cox, K. Ask, A. C. Doxey, J. A. Hirota
This study identifies ABCF1 as a cytosolic nucleic acid sensor in human airway epithelial cells that modulates antiviral responses and interacts with TLR signaling.
bioRxiv · Feb 8, 2020Immunology
V. Tat, E. A. Ayaub, A. Ayoub, M. Vierhout, S. Naiel, M. Padwal, S. Abed, O. Mekhael, K. Tandon, S. D. Revill, T. Yousof, P.-S. Bellaye, P. Kolb, A. Dvorkin-Gheva, A. Naqvi, , K. Ask
This study shows FKBP13 is upregulated in interstitial lung diseases and correlates with disease severity, suggesting a protective role against fibrosis.
bioRxiv · Dec 15, 2019Pathology
R. Jimenez-Saiz, V. C. Anipindi, H. Galipeau, Y. Ellenbogen, R. Chaudhary, J. F. Koenig, M. E. Gordon, T. D. Walker, T. S. Mandur, S. Abed, A. Humbles, D. K. Chu, J. Erjefalt, K. Ask, E. F. Verdu, M. Jordana
This study shows that gut microbes regulate intestinal eosinophils, affecting tissue repair and allergic responses to food.
bioRxiv · Sep 26, 2019Immunology