Author

D. Sprott

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Jones· 1 shared A. Linkermann· 1 shared A. Rösen-Wolff· 1 shared B. D. Piening· 1 shared B. Fox· 1 shared B. H. Falkenburger· 1 shared C. Ballesteros-Merino· 1 shared C. Bifulco· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperImmunology

A. Jones

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling

H. Luksch, F. Schulze, D. Geissler-Lösch, D. Sprott, L. Höfs, E. M. Szegö, W. Tonnus, S. Winkler, C. Günther, A. Linkermann, R. Behrendt, L. L. Teichmann, B. H. Falkenburger, A. Rösen-Wolff

This study shows that constitutive STING activation in mice causes SAVI, and TNF signaling mediates its pathogenesis, with TNFR1/2 inhibition improving disease symptoms.

bioRxiv · Apr 25, 2024Immunology

FcyRIIB is a novel immune checkpoint in the tumor microenvironment limiting activity of Treg-targeting antibodies

D. A. Knorr, R. Leidner, S. Jensen, R. Meng, A. Jones, C. Ballesteros-Merino, R. B. Bell, M. Baez, D. Sprott, C. Bifulco, B. D. Piening, R. Dahan, B. Fox, J. Ravetch

This paper identifies FcyRIIB as an inhibitory Fc receptor limiting Treg depletion by anti-CTLA-4 antibodies and shows Fc engineering can enhance their efficacy.

bioRxiv · Jan 19, 2023 · PreprintImmunology