R. Behrendt

Selective inflammation of the tumor microenvironment and invigorated T cell-mediated tumor control upon induced systemic inactivation of TREX1

This study shows that systemic TREX1 inhibition enhances anti-tumor immunity by increasing T cell infiltration and activity in tumors while sparing other tissues.

Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling

This study shows that constitutive STING activation in mice causes SAVI, and TNF signaling mediates its pathogenesis, with TNFR1/2 inhibition improving disease symptoms.

Clearance of genome-damaged cells from the hematopoietic system via p53 without contribution by the cGAS/STING axis

This study shows that p53 clears genome-damaged hematopoietic cells without needing the cGAS/STING pathway, and that cGAS/STING is not required for coping with DNA damage or preventing leukemia in RER-deficient conditions.

Validation of an RNase H2 activity assay suitable for clinical screening

The paper validates a FRET-based assay for measuring RNase H2 activity in clinical samples, showing it can detect reduced activity in patient lymphocytes.

cGAS/STING-DEPENDENT SENSING OF ENDOGENOUS RNA

The paper shows that loss of SAMHD1 leads to chronic DNA damage and cGAS/STING-dependent type I interferon production in mice, linking it to autoimmunity and cancer.

Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

This study shows that Lamin A/C protects lung alveolar macrophages from nuclear envelope rupture and aging-related DNA damage, linking NE disruption to genomic instability and senescence.

Filaggrin deficient mice have a lower threshold for cutaneous allergen sensitization but do not develop spontaneous skin inflammation or atopy

This study shows that Flg-deficient mice do not develop spontaneous skin inflammation or atopy, but Flg deficiency may modulate dermatitis caused by other barrier defects.