Author

S. Winkler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Cell Biology· 1 Ecology· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:comparative / phylogenetic analysis· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

M. Pippel· 3 shared B. Yi· 2 shared D. Burguera· 2 shared H. Strandt· 2 shared J. Horejs-Hoeck· 2 shared R. Bauer· 2 shared S. Schaller· 2 shared T. Neuper· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersEvolutionary Biology

M. Pippel

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Author profile →

8 papers

Recent·Most cited

Expanded olfactory system in fishes capable of terrestrial exploration

D. Burguera, F. Dionigi, K. Kverkov, S. Winkler, T. Brown, M. Pippel, Y. Zhang, M. Shafer, A. L. A. Nichols, E. Myers, P. Nemec, Z. Musilova

The paper examines the relationship between ecological traits and olfactory receptor gene expansions in ray-finned fishes, finding convergent increases in olfactory system size in amphibious species.

bioRxiv · Dec 5, 2022Evolutionary Biology

The NLRP3/eIF2 axis drives cell cycle progression in acute myeloid leukemia

M. Luciano, C. Blöchl, J. Vetter, L. Urwanisch, T. Neuper, D. P. Elmer, R. Bauer, H.-H. Dang, H. Strandt, D. Neureiter, P. Krenn, S. Tesanovic, S. Rieser, O. Bergsleitner, L. Zell, , J. Horejs-Hoeck

This study shows that inhibiting the NLRP3 inflammasome reduces AML cell proliferation by promoting eIF2 phosphorylation and cell cycle arrest.

bioRxiv · Jun 25, 2021 · PreprintImmunology

Phylogenetic analysis of SARS-CoV-2 lineage development across the first and second waves in Eastern Germany, 2020

B. Yi, A. R. Poetsch, M. Stadtmueller, F. Rost, S. Winkler, A. H. Dalpke

The paper analyzes SARS-CoV-2 lineage development in Eastern Germany during the first and second waves, identifying new variants introduced in 2020 as the main cause of the second wave.

bioRxiv · Apr 29, 2021 · PreprintMicrobiology

Filaggrin deficient mice have a lower threshold for cutaneous allergen sensitization but do not develop spontaneous skin inflammation or atopy

L. Muhandes, M. Pippel, M. Chapsa, R. Behrendt, Y. Ge, A. Dahl, B. Yi, A. Dalpke, S. Winkler, M. Hiller, S. Beissert, R. Jessberger, P. G. Fallon, A. Roers

This study shows that Flg-deficient mice do not develop spontaneous skin inflammation or atopy, but Flg deficiency may modulate dermatitis caused by other barrier defects.

bioRxiv · Sep 11, 2020 · PreprintImmunology

Laser-facilitated epicutaneous immunotherapy with hypoallergenic beta-glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma

E. Korotchenko, V. Schiessl, S. Scheiblhofer, I. Joubert, H. Strandt, T. Neuper, M. Sarajlic, R. Bauer, M. Geppert, D. Joedicke, S. Wildner, S. Schaller, S. Winkler, G. Gadermaier, J. Horejs-Hoeck, R. Weiss

This study shows that LamOVA, a hypoallergenic beta-glucan neoglycoconjugate, suppresses lung inflammation and reduces side effects in a mouse asthma model when delivered via laser-facilitated epicutaneous immunotherapy.

bioRxiv · Jan 18, 2020Immunology

Multiple layers of phospho-regulation coordinate metabolism and the cell cycle in budding yeast

L. Zhang, S. Winkler, F. Schlottmann, O. C. Kohlbacher, J. E. Elias, J. M. Skotheim, J. C. Ewald

This study identifies cell cycle-dependent phosphorylation and dephosphorylation of metabolic enzymes in budding yeast, revealing mechanisms linking the cell cycle to metabolic regulation.

bioRxiv · Oct 22, 2019Cell Biology

Evolved for success in novel environments: the round goby genome

I. Adrian-Kalchhauser, A. Blomberg, T. Larsson, Z. Musilova, C. R. Peart, M. Pippel, M. Hongroe Solbakken, J. Suurvaeli, J.-C. Walser, J. Y. Wilson, M. Alm Rosenblad, D. Burguera, S. Gutnik, N. Michiels, M. Toepel, , S. Winkler

The paper presents a long-read genome assembly of the round goby and identifies gene family expansions associated with its ecological success in novel environments.

bioRxiv · Aug 6, 2019Ecology

SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate

M. J. Roy, S. Winkler, S. J. Hughes, C. Whitworth, M. Galant, W. Farnaby, K. Rumpel, A. Ciulli

This paper develops an SPR-based assay to measure PROTAC ternary complex dissociation kinetics and shows that differences in off-rates correlate with target degradation efficiency.

bioRxiv · Feb 3, 2019Biochemistry