D. Standing

DCLK1-Mediated Regulation of Invadopodia Dynamics and Matrix Metalloproteinase Trafficking Drives Invasive Progression in Head and Neck Squamous Cell Carcinoma

This study identifies DCLK1's role in regulating invadopodia dynamics and MMP trafficking in HNSCC, showing its impact on invasion and metastasis.

IRAK1 is a critical mediator of low molecular weight hyaluronic acid-induced stemness in high-grade serous ovarian cancer

This study identifies IRAK1 as a key mediator of LMW HA-induced stemness in EOC, showing its role in chemoresistance and demonstrating TCS2210 as a potential inhibitor.

Doublecortin like kinase 1 is a target in squamous cell carcinoma

This study identifies DCLK1 as a critical target in squamous cell carcinoma, showing its role in tumor growth and demonstrating a selective inhibitor, DiFiD, that suppresses cancer progression.

RNA binding protein RBM3 augments kissing loop formation with lncRNAs to enhance translational control

This study identifies RBM3's role in enhancing translational control via lncRNA kissing loop formation and shows its impact on tumor growth and colitis-associated cancers.

Ureides are similarly accumulated in response to UV-C irradiation and wound but differently remobilized during recovery in Arabidopsis leaves.

This study shows that UV-C and wounding trigger purine degradation in Arabidopsis, leading to ureide accumulation, which is remobilized differently during recovery to support growth or healing.