L. Li

Caspase-1 and -11 defend against environmental but not host-adapted pathogens in genetically complex mice

This study shows that caspase-1 and -11 protect against environmental pathogens but not host-adapted ones in genetically diverse mice.

Direct interactions of CEACAM1 and CD36 with micellar LPS and each other

This study investigates the direct interactions of CEACAM1 and CD36 with micellar LPS and each other, revealing cooperative binding and implications for innate immunity and lipid metabolism.

The Risk of Gulf Birds Functional Diversity Loss with Climate Change Uncovered Using Deep Learning Population Models

The paper uses deep learning to model how climate change and sea-level rise affect bird functional diversity in the Gulf of America, finding unexpected declines in upland areas and increases in shoreline diversity.

KMT2d regulates tooth enamel development

This study investigates the role of KMT2D in amelogenesis using a conditional knockout mouse model, revealing its critical role in enamel development and identifying direct target genes involved in ameloblast differentiation.

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Ancestral SARS-CoV-2 immune imprinting persists on RBD but not NTD after sequential Omicron infections

The paper examines how sequential Omicron infections affect ancestral SARS-CoV-2 immune imprinting, finding that it persists on the RBD but not the NTD.

Substructure and maturation of lamina-associated domains in neurons of the developing and adult human brain

The paper investigates the substructure and maturation of lamina-associated domains (LADs) in postmitotic neurons across human brain development, revealing dynamic changes in T1 and T2 LADs.

Systematic Multi-Omics Investigation of Androgen Receptor Driven Gene Expression and Epigenetics changes in Prostate Cancer

This study investigates AR-driven gene expression and epigenetic changes in prostate cancer using multi-omics data from LNCaP cells, identifying gene expression shifts and AR binding patterns under androgen deprivation therapy.

An extinct clade sister to Eumetazoa: On the phylogeny of the Cambrian chancelloriids

This study describes new fossils of chancelloriids, revealing their unique body plan and suggesting they are a basal clade sister to eumetazoans.

A Novel Registration Framework for Aligning Longitudinal Infant Brain Tensor Images

This paper introduces a groupwise registration framework for longitudinal infant DTI images, improving alignment accuracy through clustering and sample-specific common space alignment.

Microbial single-cell omics in situ

The paper reports a method using LIFT technology to obtain high-quality microbial single-cell genomes or transcriptomes from complex samples and demonstrates its application to study cell-fate commitment in sporulation.

Hepatic Nrf1 (Nfe2l1) promotes VLDL dependent liver defense against sepsis

This study shows hepatic Nrf1 promotes VLDL-dependent liver defense against sepsis by enhancing stress defenses and improving survival.

Agent-Based Modeling of Virtual Tumors Reveals the Critical Influence of Microenvironmental Complexity on Immunotherapy Efficacy

This study compares ODE and ABM models to show how spatial components affect immunotherapy outcomes in tumors with different antigenicity and CTL killing mechanisms.

Microglia mediate the early-life programming of adult glucose control

This study shows that microglia in the mediobasal hypothalamus prune synapses during early life, influencing adult glucose control through perineuronal net refinement.

Dynamic Localization of Leukemia Stem Cells via CXCL12 Regulates Leukemia Progression

This study shows that the CXCL12 gradient, regulated by DPP4 and GPC3, determines leukemia stem cell (LSC) localization and behavior, influencing leukemia progression.

Scalable intracellular delivery via microfluidic vortex shedding enhances the function of chimeric antigen receptor T-cells

This study introduces hydroporation as a scalable and efficient method for delivering CAR-T cells, achieving higher yields and viability compared to traditional methods.

The RAE1-STOP1 Module Reduces Sensitivity to Exogenous ABA Treatment by Regulating ABI5 in Arabidopsis

The paper identifies the RAE1-STOP1 module as a negative feedback loop that reduces ABA sensitivity by preventing ABI5 upregulation in Arabidopsis.

Electrostatic interactions in nucleosome and higher-order structures are regulated by protonation state of histone ionizable residue

The paper investigates how changes in histone protonation states affect nucleosome electrostatic potentials and interactions with partner proteins, and how cancer mutations influence these interactions.

How does the ion concentration affect the functions of kinesin BimC

This study investigates how ion concentration affects BimC's function by analyzing electrostatic interactions between BimC and microtubules using molecular dynamics simulations.

CRISPR Double Knockout Library Reveals Synthetic Lethal Gene Pairs in Triple-Negative Breast Cancer

Identifying Novel Therapeutic Targets for Overcoming TNBC Chemo Resistance Through Comprehensive CRISPR-Cas9 Genome Screening

This study uses CRISPR-Cas9 and RNAseq to identify novel synthetic lethal targets in TNBC cells resistant to cisplatin/doxorubicin, highlighting potential drug targets for combination therapies.

SS18::SSX redistributes BAF chromatin remodelers selectively to activate and repress transcription

This paper shows SS18::SSX fusion protein alters BAF chromatin remodeler distribution, leading to transcriptional activation and repression by changing histone modifications at regulatory regions.

Epithelial NSD2 maintains FMOs-mediated taurine biosynthesis to prevent intestinal barrier disruption

The paper shows NSD2 maintains taurine biosynthesis via FMOs in intestinal epithelial cells, preventing barrier disruption in IBD.

Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Non-structural Proteins Inhibitors

This study uses covalent DNA-encoded libraries to discover inhibitors targeting SARS-CoV-2 proteases 3CLpro and PLpro, identifying novel compounds with potent activity and unique binding modes.

MoLst8 regulates autophagy and lipid homeostasis in Magnaporthe oryzae

This study investigates the role of MoLst8 in autophagy and lipid homeostasis in Magnaporthe oryzae, showing its positive regulation of TORC1 and disruption of lipid metabolism in a knockout mutant.

Riluzole reverses blood-testis barrier loss to rescue chemotherapy induced male infertility by binding to TRPC

This study shows riluzole restores blood-testis barrier function and rescues chemotherapy-induced male infertility in mice by targeting TRPC5.

Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.

Harnessing defective interfering particles and lipid nanoparticles for effective delivery of an anti-dengue virus RNA therapy

This paper demonstrates that DI290-loaded lipid nanoparticles (LNP-290) effectively suppress DENV infection in cell cultures and mice, inducing IFN responses and preventing clinical signs.

The ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS)

This paper identifies TMX2 as a regulator of ER-mitochondria contacts by preventing TOM70 sulfenylation, linking its dysfunction to neurodevelopmental disorders.

DCLK1-Mediated Regulation of Invadopodia Dynamics and Matrix Metalloproteinase Trafficking Drives Invasive Progression in Head and Neck Squamous Cell Carcinoma

This study identifies DCLK1's role in regulating invadopodia dynamics and MMP trafficking in HNSCC, showing its impact on invasion and metastasis.