S. M. Thomas

DCLK1-Mediated Regulation of Invadopodia Dynamics and Matrix Metalloproteinase Trafficking Drives Invasive Progression in Head and Neck Squamous Cell Carcinoma

This study identifies DCLK1's role in regulating invadopodia dynamics and MMP trafficking in HNSCC, showing its impact on invasion and metastasis.

Rapid lethality of mice lacking the phagocyte oxidase and Caspase1/11 following Mycobacterium tuberculosis infection.

This study shows that mice lacking both phagocyte oxidase and Caspase1/11 die rapidly from tuberculosis due to severe inflammation and bacterial growth.

Doublecortin like kinase 1 is a target in squamous cell carcinoma

This study identifies DCLK1 as a critical target in squamous cell carcinoma, showing its role in tumor growth and demonstrating a selective inhibitor, DiFiD, that suppresses cancer progression.

RNA binding protein RBM3 augments kissing loop formation with lncRNAs to enhance translational control

This study identifies RBM3's role in enhancing translational control via lncRNA kissing loop formation and shows its impact on tumor growth and colitis-associated cancers.

Tissue architectural cues drive organ targeting of human tumor cells in zebrafish

The paper shows human tumor cells preferentially colonize specific tissues in zebrafish based on vessel topography and integrin expression, revealing mechanisms of metastatic organ targeting.