S. Umar

RV-specific Targeting of Snai1 Rescues Pulmonary Hypertension-induced Right Ventricular Failure by Inhibiting EndMT and Fibrosis via LOXL2 Mediated Mechanism

This study shows that targeting Snai1 in the right ventricle rescues pulmonary hypertension-induced failure by reducing EndMT, fibrosis, and FMT through a LOXL2-dependent mechanism.

DCLK1-Mediated Regulation of Invadopodia Dynamics and Matrix Metalloproteinase Trafficking Drives Invasive Progression in Head and Neck Squamous Cell Carcinoma

This study identifies DCLK1's role in regulating invadopodia dynamics and MMP trafficking in HNSCC, showing its impact on invasion and metastasis.

An improved mouse model of sepsis based on intraperitoneal injections of the enriched culture of cecum slurry

The paper introduces an improved sepsis model in mice using intraperitoneal injection of enriched cecal slurry cultures, enabling reproducible and ethical sepsis induction.

Doublecortin like kinase 1 is a target in squamous cell carcinoma

This study identifies DCLK1 as a critical target in squamous cell carcinoma, showing its role in tumor growth and demonstrating a selective inhibitor, DiFiD, that suppresses cancer progression.

Comparative Analysis of Right Ventricular Metabolic Reprogramming in Pre-clinical Rat Models of Severe Pulmonary Hypertension-induced Right Ventricular Failure

This study compares metabolic reprogramming in the right ventricle of two rat models of severe pulmonary hypertension-induced right ventricular failure, identifying common and distinct metabolic signatures.

RNA binding protein RBM3 augments kissing loop formation with lncRNAs to enhance translational control

This study identifies RBM3's role in enhancing translational control via lncRNA kissing loop formation and shows its impact on tumor growth and colitis-associated cancers.