The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors
R. W. Robey, C. M. Fitzsimmons, W. M. Guiblet, W. J. E. Frye, J. Gonzalez Dalmasy, L. Wang, D. A. Russell, L. M. Huff, A. J. Perciaccante, F. Ali-Rahmani, C. C. Lipsey, H. M. Wade, A. V. Mitchell, S. S. Maligireddy, D. Terrero, , P. J. Batista
This study identifies METTL7A and METTL7B as methyltransferases that confer resistance to thiol-based HDAC inhibitors by modifying the drug's zinc-binding thiol.
bioRxiv · Oct 7, 2022Cancer Biology