D. Butcher

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

Spatial analysis of NOS2 and COX2 interaction with T-effector cells reveals immunosuppressive landscapes associated with poor outcome in ER- breast cancer patients

The paper identifies spatial interactions between NOS2, COX2, and T-effector cells in ER- breast cancer, linking these patterns to poor patient outcomes and suggesting potential therapeutic strategies.

NOS2 and COX2 Provide Key Spatial Targets that Determine Outcome in ER- Breast Cancer

This study identifies NOS2 and COX2 as key spatial targets in ER- breast cancer that influence immune phenotypes and clinical outcomes through spatial analysis of tumor microenvironments.

UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer.

This study identifies UGDH as a driver of tumor-initiating cells and fibroinflammatory microenvironment in ovarian cancer, with subtype-specific effects on prognosis and tumor growth.

Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood-brain barrier

The paper identifies Abcg2a as the functional homolog of human ABCG2 at the zebrafish blood-brain barrier, showing its substrate overlap and BBB localization.

Interferon-gamma is Quintessential for NOS and COX Expression in ER- Breast Tumors that Lead to Poor Outcome

The paper shows IFN-gamma induces NOS2 and COX2 in ER-breast tumors, linked to poor outcomes, through spatial analysis of tumor microenvironments.

The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors

This study identifies METTL7A and METTL7B as methyltransferases that confer resistance to thiol-based HDAC inhibitors by modifying the drug's zinc-binding thiol.

NOS2 and COX2 Blockade Limits TNBC Disease Progression and Alters CD8+ T Cell Spatial Orientation and Density

This paper shows that blocking NOS2 and COX2 reduces TNBC tumor growth and improves CD8+ T cell infiltration and spatial distribution in tumors.

Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter

This study characterizes zebrafish homologs of the human ABCB1 gene, showing that abcb4 closely resembles P-gp in function and localization, while abcb5 differs.

Solution and gas-phase modifiers effect on heme proteins environment and conformational space

This study examines how solution additives and gas-phase modifiers affect the conformational states of heme proteins using trapped ion mobility spectrometry.