Cancer BiologybioRxiv
The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors
R. W. Robey, C. M. Fitzsimmons, W. M. Guiblet…·P. J. Batista
This study identifies METTL7A and METTL7B as methyltransferases that confer resistance to thiol-based HDAC inhibitors by modifying the drug's zinc-binding thiol.