Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity
S. D. Martin, T. Connor, A. Sanigorski, K. A. McEwen, D. C. Henstridge, B. Nijagal, D. P. De Souza, D. Tull, P. Meikle, G. M. Kowalski, C. Bruce, P. Gregorevic, M. Febbraio, F. Collier, K. R. Walder, S. McGee
This study shows that HDAC4 and HDAC5 inhibit cell death pathways and protect muscle integrity by reducing oxidative metabolism and promoting survival under lipotoxic stress.
bioRxiv · Oct 17, 2022Cell Biology