Neuronal-specific function of hTim8a in Complex IV assembly provides insight into the molecular mechanism underlying Mohr-Tranebjaerg syndrome
Y. Kang, A. J. Anderson, D. P. De Souza, C. S. Palmer, K. M. Fujihara, T. Stait, A. E. Frazier, N. J. Clemons, D. Tull, D. R. Thorburn, M. J. McConville, M. T. Ryan, D. A. Stroud, D. Stojanovski
This study identifies hTim8a's role in neuronal Complex IV assembly and shows how its loss causes oxidative stress and apoptosis, contributing to Mohr-Tranebjaerg syndrome.
bioRxiv · Aug 5, 2019 · PreprintCell Biology