The N-terminal region of DNMT3A combines multiple chromatin reading motifs to guide recruitment.
H. Wapenaar, G. Clifford, W. Rolls, H. Burdett, Y. Zhang, G. Deak, J. Zou, M. R. Taylor, J. Mills, J. A. Watson, D. Kumar, A. Das, D. Valsakumar, J. Bramham, P. Voigt, M. D. Wilson
This study identifies the N-terminal region of DNMT3A as containing multiple chromatin-binding motifs that mediate recruitment through interactions with nucleosomes and ubiquitylated histone H2AK119.
bioRxiv · Oct 29, 2023Biochemistry