Probing Ligand and Cation Binding Sites in G-Quadruplex Nucleic Acids by Mass Spectrometry and Electron Photodetachment Dissociation Sequencing
D. Paul, A. Marchand, D. Verga, S. Bombard, M.-P. Teulade-Fichou, F. Rosu, V. Gabelica
The paper develops a mass spectrometry method to determine cation and ligand binding sites in G-quadruplex DNA without derivatization, revealing that 360A and PhenDC3 bind near the central loop of telomeric sequences.
bioRxiv · Apr 4, 2019Biophysics