F. Rosu

Negative Electrospray Supercharging Mechanisms of Oligonucleotide Single Strands and G-quadruplexes

This study investigates how negative electrospray supercharging of nucleic acids can be achieved while preserving native structures, finding that certain solvents enhance supercharging but may also cause unfolding.

Probing Ligand and Cation Binding Sites in G-Quadruplex Nucleic Acids by Mass Spectrometry and Electron Photodetachment Dissociation Sequencing

The paper develops a mass spectrometry method to determine cation and ligand binding sites in G-quadruplex DNA without derivatization, revealing that 360A and PhenDC3 bind near the central loop of telomeric sequences.

Thermal Denaturation of DNA G-Quadruplexes and their Complexes with Ligands: Thermodynamic Analysis of the Multiple States Revealed by Native Mass Spectrometry

This study uses native mass spectrometry to analyze the thermodynamics of G-quadruplex DNA denaturation and ligand binding, revealing enthalpic and entropic contributions to stability and ligand specificity.

Compaction of Duplex Nucleic Acids upon Native Electrospray Mass Spectrometry

This study shows that DNA and RNA duplexes become more compact in the gas phase under native electrospray conditions compared to their solution structures.