D. Paul

Loss of FBXO31-mediated γH2AX foci formation impairs initiation of NHEJ and HR repair pathways, and sensitizes breast cancer to therapy

This study shows that FBXO31-mediated γH2AX foci formation is essential for DNA repair pathways and that its loss sensitizes breast cancer to chemotherapy.

Evaluation of extraction solvents for untargeted metabolomics to decipher the dissolved organic matter of Antarctic cryoconite holes

This study evaluates solvent combinations for untargeted metabolomics to analyze dissolved organic matter in Antarctic cryoconite holes, finding that specific solvent mixtures enhance metabolite detection.

Valproic Acid Treatment Enhances Chromosome Flexibility and Electron Transport in MCF7 Breast Cancer Cells

This study examines how Valproic Acid affects chromosome flexibility and electron transport in MCF7 breast cancer cells using atomic force microscopy and electron transport analysis.

Evidence for intrinsic DNA dynamics and deformability in damage sensing by the Rad4/XPC nucleotide excision repair complex

The paper investigates DNA dynamics and deformability in Rad4/XPC damage sensing using T-jump and FRET techniques, showing rapid fluctuations and unwound/bent conformations at lesion sites.

Measuring RBC deformability and its heterogeneity using a fast microfluidic device

The paper introduces a microfluidic device to measure RBC deformability and Young's modulus, showing stiffer RBCs deflect more and enabling sorting based on deformability.

Activity and abundance of nitrous oxide consuming bacteria in Platismatia glauca cryptogamic lichen in boreal Finnish spruce forest.

The paper investigates N2O consumption by Platismatia glauca lichen in boreal forests, showing increased consumption at lower temperatures and through denitrification under nitrogen limitation.

Pump-free and high-throughput generation of monodisperse hydrogel beads by microfluidic step emulsification for dLAMP-on-a-chip

This paper develops a pump-free microfluidic method to generate monodisperse hydrogel beads for dLAMP-on-a-chip, enabling high-throughput nucleic acid amplification with minimal sample volume.

Functional antagonistic interactions and genomic insights into the biosynthetic potential of human gut-derived microbiota

The paper identifies antagonistic interactions and biosynthetic gene clusters in human gut microbiota, highlighting their therapeutic potential and role in combating antibiotic resistance.

Anomalous diffusion of E. coli under microfluidic confinement and chemical gradient

This study investigates how confinement and chemical gradients affect E. coli motility, finding super-diffusive behavior under these conditions.

Oral glucose feeding enhances adherence of quiescent lymphocytes to fibronectin via non-canonical insulin signalling.

The paper shows oral glucose increases lymphocyte adhesion to fibronectin via non-canonical insulin signaling involving IGF-1R and PLCγ1.

Convergent use of phosphatidic acid for Hepatitis C virus and SARS-CoV-2 replication organelle formation

This study identifies phosphatidic acid as critical for double membrane vesicle formation in HCV and SARS-CoV-2 replication, suggesting host-targeted PA synthesis inhibition as a therapeutic strategy.

Analysis of variability of functionals of recombinant protein production trajectories based on limited data

The paper develops a bootstrap-based method to infer variability in functionals of protein production trajectories from limited data, applied to time-to-harvest and maximal productivity.

Modelling Human Gait using a Nonlinear Differential Equation

The paper models human gait using a nonlinear differential equation based on 3D visualization of center of mass movement during walking or running.

Temperature-dependent Self assembly of biofilaments during red blood cell sickling

The paper studies the temperature-dependent lag time in hemoglobin fiber self-assembly using kinetic Monte-Carlo simulations, showing non-monotonic behavior with temperature changes.

Tethering-facilitated DNA 'opening' and complementary roles of β-hairpin motifs in the Rad4/XPC DNA damage sensor protein

This study shows Rad4/XPC can open undamaged DNA in solution without specific β-hairpin motifs and reveals dynamic conformations of open DNA through crystal structures and fluorescence analysis.

Light-induced modulation of DNA recognition by the Rad4/XPC damage sensor protein

This paper shows that light can control DNA binding by the Rad4/XPC repair complex using photoswitchable DNA, revealing structural changes in DNA upon binding.

Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion

In vivo characterisation of endogenous cardiovascular extracellular vesicles in larval and adult zebrafish

This study develops a transgenic zebrafish model to track and extract endogenous cardiovascular extracellular vesicles (EVs) in vivo, showing their production by multiple cell types and dynamic changes under injury.

In vitro and in silico analyses of the angiotensin-I converting enzyme inhibitory activity of peptides identified from Bellamya bengalensis protein hydrolysates

The paper identifies ACE-inhibitory peptides from Bellamya bengalensis protein hydrolysates and examines their mechanism through in vitro and in silico analyses.

Proteins and Ions Compete for Membrane Interaction: the case of Lactadherin

This study investigates how lactadherin interacts with phosphatidylserine lipids in the presence and absence of calcium ions, revealing how calcium affects these interactions and their role in blood coagulation.

Depletion of nuclear pore protein NUP210 suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

This study identifies NUP210 as a metastasis susceptibility gene in ER+ breast cancer, showing its role in mechanosensation through heterochromatin-mediated disruption of mechanotransduction.

Impact of DNA sequences in the DNA duplex opening by the Rad4/XPC nucleotide excision repair complex

This study shows that DNA sequences affect how Rad4/XPC opens DNA duplexes, with some sequences resisting opening despite prolonged Rad4 binding.

A fast microfluidic device to measure the deformability of red blood cells

This paper introduces a microfluidic device to measure red blood cell deformability, showing it can estimate elastic constants and sort cells based on deformability.

Probing Ligand and Cation Binding Sites in G-Quadruplex Nucleic Acids by Mass Spectrometry and Electron Photodetachment Dissociation Sequencing

The paper develops a mass spectrometry method to determine cation and ligand binding sites in G-quadruplex DNA without derivatization, revealing that 360A and PhenDC3 bind near the central loop of telomeric sequences.

An integrated one-step assay combining thermal lysis and loop-mediated isothermal DNA amplification (LAMP) in 30 min from E. coli and M. smegmatis cells on a paper substrate

Emergence of Multidrug-Resistant Uropathogens harboring ESBL, Carbapenem, Aminoglycosides and AmpC resistant genes from Northern India

This study reports the prevalence of multidrug-resistant uropathogens in Northern India, highlighting the co-occurrence of ESBL, carbapenem, aminoglycoside, and AmpC resistance genes.

Clogging-free continuous operation with whole blood in a radial pillar device (RAPID)

The paper describes a modified radial pillar device (RAPID) that enables clog-free operation with whole blood for continuous cell separation and demonstrates platelet enrichment.

A radial pillar device (RAPID) for continuous and high-throughput separation of multi-sized particles

The paper introduces RAPID, a microfluidic device that separates multi-sized particles efficiently and continuously, achieving high purity and recovery.