D. Wacker

Molecular Basis of Human Trace Amine-Associated Receptor 1 Activation

This study determines the structure of hTAAR1 in complex with Gs and reveals its pharmacological differences from rodent orthologs, showing asenapine activates hTA1.

Substrate Binding and Inhibition of the Anion Exchanger 1 Transporter

The paper presents high-resolution cryo-EM structures of the full-length human AE1 transporter in various states, revealing substrate binding, inhibition mechanisms, and lipid/sterol binding sites.