Substrate Binding and Inhibition of the Anion Exchanger 1 Transporter
M. J. Capper, S. Yang, A. C. Stone, S. Vatansever, G. Zilberg, Y. K. Mathiharan, R. Habib, K. Hutchinson, A. Schlessinger, M. Mezei, R. Osman, B. Zhang, D. Wacker
The paper presents high-resolution cryo-EM structures of the full-length human AE1 transporter in various states, revealing substrate binding, inhibition mechanisms, and lipid/sterol binding sites.
bioRxiv · Feb 11, 2022Biochemistry