Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse and widespread in the environment.
M. Monteiro Pedroso, D. Waite, O. Melse, L. Wilson, N. Mitic, R. P. McGeary, I. Antes, L. W. Guddat, P. Hugenholtz, G. Schenk
The paper identifies a broad phylogenetic diversity of B3 MBLs in environmental microbes and shows that a variant (B3-RQK) is sensitive to clavulanic acid due to a lysine residue in its active site.
Protein & Cell · Jun 15, 2020Peer-reviewedBiochemistry