L. W. Guddat

The paper reports the structures of M. tuberculosis cytochrome bcc complexed with two anti-TB drugs, revealing binding sites and interactions that inform inhibitor design.

The paper identifies a broad phylogenetic diversity of B3 MBLs in environmental microbes and shows that a variant (B3-RQK) is sensitive to clavulanic acid due to a lysine residue in its active site.

This study shows Carmofur inhibits SARS-CoV-2 main protease by covalently binding to Cys145 and occupying the S2 subsite, with an EC50 of 24.30 M in cell-based viral replication assays.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

The paper identifies structural elements in plant purple acid phosphatases that influence substrate specificity, offering insights for improving phosphorus acquisition in crops.