Author

Dan Yang

Coriell Institute For Medical Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Anthony PompettiiD· 2 shared Dongwook Kim· 2 shared Gennaro CalendoiD· 2 shared Jian Yuan HuangiD· 2 shared Srinivas ChatlaiD· 2 shared Xiaoyu WeiiD· 2 shared Yun LiaoiD· 2 shared Zhen TianiD· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersCancer Biology

Anthony PompettiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Ribonucleotide Reductase Inhibition Overcomes FLT3 Inhibitor Resistance in Acute Myeloid Leukemia

Zhen Tian, Xiaoyu Wei, Srinivas Chatla, Yang Liu, Dongwook Kim, Yahui Li, Peng Wang, Yun Liao, Xiaolei Liu, Dan Yang, Stacia Octaviani, Gui Ma, Anthony Pompetti, Gennaro Calendo, Martin P. Keough, , Jian Yuan Huang

This paper identifies RNR inhibition as a strategy to overcome FLT3 inhibitor resistance in FLT3ITD+ AML by reversing resistance mechanisms and enhancing therapeutic efficacy.

bioRxiv · Jul 22, 2026 · PreprintCancer Biology

Targeting Cellular Pseudo-Senescence to Overcome PARP inhibitors Resistance in BRCA1 -Mutated Breast Cancer

Zhen Tian, Srinivas Chatla, Shreya Indulkar, Dongwook Kim, Xiaoyu Wei, Yun Liao, Dan Yang, Anthony Pompetti, Gennaro Calendo, Congli Wang, Tina Bocker Edmonston, Zhenkun Lou, Tomasz Skórski, Liewei Wang, Jian Yuan Huang

This study identifies ZNF251 deficiency as a driver of PARP inhibitor resistance in BRCA1-mutant breast cancer, showing that targeting pseudo-senescence with senomorphic or senolytic therapies can overcome resistance.

bioRxiv · Jun 26, 2026 · PreprintCancer Biology

Physics-inspired computational methods for spatial transcriptomics reveal a dysplasia-restricted premalignant basin and a density-asymmetric autocrine niche in oral mucosal carcinogenesis

Zhenyuan Huang, Dan Yang, Rui Zhang, Qianming Chen, Hang Zhao, Hao Xu

The paper introduces three physics-inspired computational methods for spatial transcriptomics to analyze oral mucosal carcinogenesis, identifying a dysplasia-restricted MRB cluster with autocrine signaling and a density-asymmetric niche.

bioRxiv · Apr 29, 2026 · PreprintBioinformatics