Peng Wang

This paper identifies RNR inhibition as a strategy to overcome FLT3 inhibitor resistance in FLT3ITD+ AML by reversing resistance mechanisms and enhancing therapeutic efficacy.

This paper predicts SARS-CoV-2 RBD evolution using deep mutational scanning to identify broadly neutralizing antibodies effective against existing and prospective variants.

This study shows that SARS-CoV-2 variants KP.3.1.1 and XEC have enhanced immune evasion through NTD glycosylation, despite maintaining high ACE2 binding and infectivity.

This study investigates how N354 glycosylation in the SARS-CoV-2 spike protein affects viral fitness and human adaptation through multiple mechanisms.

This study assesses the antigenic properties and immune evasion of the SARS-CoV-2 variant BA.2.87.1, finding it less resistant to neutralizing antibodies than JN.1 but with compensatory deletions in the NTD.

The paper analyzes antibody neutralization data from multiple countries to assess how prior exposure to SARS-CoV-2 variants affects neutralization profiles of BA.2.86 and its descendants.

This study shows that convergent evolution of SARS-CoV-2 XBB lineages at RBD positions 455-456 synergistically enhances antibody evasion and ACE2 binding through epistatic interactions.

The paper shows JN.1 outcompetes BA.2.86 and other variants by evading antibodies more effectively, despite reduced ACE2 binding.

This study characterizes the antigenic properties and infectivity of the SARS-CoV-2 BA.2.86 variant, finding it evades immune responses but has reduced infectivity compared to previous variants.