Molecular BiologyNature CommunicationsPeer-reviewed
Engineered transcription-associated Cas9 targeting in eukaryotic cells
Gregory W. Goldberg, Manjunatha Kogenaru, Sarah Keegan…·Jef D. Boeke
This paper introduces a method to temporally control Cas9 DNA targeting by coupling it with transcription through engineered RNA binding, enabling selective gene editing in yeast and human cells.