Virus-free CRISPR knock-in of a chimeric antigen receptor into KLRC1 generates potent GD2-specific natural killer cells
Keerthana Shankar, Isabelle Zingler-Hoslet, Diana Marcela Tabima, Seth R. T. Zima, Lei Shi, Kirstan Gimse, Matthew H. Forsberg, Varun Katta, Sage Z. Davis, Daniel Maldonado, Brittany Russell, Muhammed Murtaza, Shengdar Q. Tsai, José María Ayuso, Christian M. Capitini, Krishanu Saha
This study uses CRISPR to disrupt an inhibitory receptor in NK cells and insert a GD2-targeting CAR, creating potent NK cells against GD2+ melanoma.
Molecular Therapy · Jan 14, 2025Peer-reviewedBioengineering