Christian M. Capitini

This study shows that low-dose radiopharmaceutical therapy enhances the effectiveness of B7-H3 CAR T cells in treating metastatic neuroblastoma in mice.

This study identifies CXCL13-CXCR5 signaling as critical for CD8 T cell recruitment and immune organization in ccRCC, with potential as a biomarker and therapeutic target.

This paper introduces a method to enhance T cell therapy by using a CAR targeting uPAR to eliminate dysfunctional T cells through directed fratricide.

This study expands and activates allogeneic canine NK cells ex vivo, demonstrating their safety and in vitro potency for treating metastatic solid tumors.

The paper shows that HK2 is essential for cytosolic HK activity and glycolytic ATP production in HPLM, supporting the Warburg effect through compartmentalized ATP synthesis.

This paper introduces a live tumor fragment platform to assess immunotherapy response in core needle biopsies, showing it can detect T-cell responses and mitigate tissue heterogeneity challenges.

This study develops mRNA lipid nanoparticles to deliver GD2 CAR genes to T and NK cells, showing effective neuroblastoma targeting and killing in vitro.

This study shows that combining TIM-3 blockade with ex vivo stimulated allogeneic NK cells improves survival and reduces tumor growth in a murine neuroblastoma model after allo-HCT without increasing GVHD.

Autofluorescence imaging informs manufacturing conditions that enhance yield and metabolic fitness of CAR T cells for neuroblastoma.

This paper shows that low-dose radiopharmaceutical therapy enhances GD2 TRAC-CAR T cell efficacy in neuroblastoma by improving tumor regression and immune response.

This study uses CRISPR to disrupt an inhibitory receptor in NK cells and insert a GD2-targeting CAR, creating potent NK cells against GD2+ melanoma.

This study shows that metabolic priming during CAR T cell manufacturing reduces glycolysis and enhances memory phenotypes, improving in vivo persistence against GD2+ tumors.

This study shows that altering the microenvironment of mesenchymal stromal cells changes exosome RNA content and improves ligament healing in rats.